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Testosterone Cypionate and Trenbolone Enanthate are both long-estered anabolic steroids and therefore are best suited for longer cycles (in this case, the aim is a 3 month or 12 week cycle of each)compared to the more short-acting analogues. This also suggests that cationic steroids may have less affinity and/or less potency on the liver where the longer/smaller durations of cycle use is less common. The use of steroids in humans appear to be associated with increased liver fibrosis in men due to the increase in circulating testosterone (testosterone sulfate) and this may be at least in part down to its ability to suppress hepatic triglycerides when injected alongside the cholesterol ester. When measuring the testosterone content before and after liver transplants, both ethinylestradiol (E2) and testosterone cypionate were significantly reduced during liver transplants in the group that received both steroids (17% in the methoxetamine group, and 30% in placebo). E2 was significantly reduced in the ethinylestradiol-treated group. Testosterone cypionate was significantly reduced relative to the placebo. This study suggests that when an anabolic steroid is absorbed into the portal vein of the liver, it accumulates to the serum and the liver can accumulate high levels of testosterone; as testosterone builds up it's ability to suppress serum fat. Other liver organ tissues (liver fibroblasts and bile duct cells) that may absorb testosterone do not appear to be affected and there appear to be a few studies which have been done with rats where the same effects were noted. The study that appears to show a reduction in liver fibrosis with ethinylestradiol is limited to rats, however. 7.3. Liver Function The liver is the main site where the testosterone comes directly into the body, and it's one that is the site where estrogenic/anabolic steroids (COCs) are bound as well. Testosterone has both direct agonist/antagonist properties, and the effects of each testosterone receptor at the liver have been noted with several different COCs. Injections of the synthetic (androgenic) testosterone propionate (TP) can increase bile acid secretion from hepatocytes which is known to be related to testosterone and it has also been noted that TTP may induce an increase in the expression of the pro-inflammatory molecule NF-kB. The mechanisms of action can be due to either TTP itself or due to Related Article: